Fibromyalgia
Advancing Treatment
About Fibromyalgia
Fibromyalgia (FM) is a widespread chronic pain disorder, including symptoms of severe pain and fatigue that last for 3 months or longer. FM is also characterized by generalized aching, muscle stiffness, non-restorative sleep, chronic fatigue, depression, cognitive impairment, and disturbances in bowel function.
Patients with FM have a problem with central pain processing. The exact causality of the heightened pain sensitivity in FM is poorly understood. What is generally agreed is that the central sensitization seen in FM is secondary to a combination of genetic and environmental factors that render the patient susceptible to developing the widespread chronic pain and related symptoms seen in FM. We believe that, when FM patients are exposed to significant life stressors, be they physical or emotional, it results in an abnormal stress which activates herpes virus mediated-immune response. Herpes viruses are unique in that they remain in a dormant state (latency) in neuronal nuclei as nonintegrated, circular DNA associated with nucleosomes, with recurrent reactivations for the life of the host (as seen here). We believe it is likely that nerve resident viral herpetic reactivation is necessary for the waxing and waning nociceptive manifestation of FM.
Unmet Medical Need
Fibromyalgia (FM) affects between 2% and as high as 8% of the total American adult population. What causes fibromyalgia isn’t well understood, but it is currently treated and managed with medication or through self-management strategies associated with lifestyle changes.
Despite a very high disease burden, just over one in two (56%) patients currently diagnosed with FM are actively being treated with prescription medication. Furthermore, the three medicines approved to treat FM can give rise to a side-effect burden which limits their use.
After they develop FM, many patients seek ways to improve their quality of life. This may be through lifestyle changes, self-care, exercise, diet, or other ways they have found to help manage their disease. Most common symptoms include relieving the condition that causes fibromyalgia pain throughout the body, sleep problems, fatigue, and often emotional and mental distress.
DISEASES
CINP
CINP Chemotherapy treatments can cause peripheral neuropathy by damaging the nerves in the extremities.
LONG COVID
Long COVID - Long COVID refers to the health problems that one may have after recovering from COVID-19.
FIBROMYALGIA
Fibromyalgia - Fibromyalgia (FM) is a widespread chronic pain disorder that lasts for 3 months or longer.
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